Journal of Biological Sciences and Medicine 2018-12-31T20:03:44+00:00 Dr. Anurag Dabas Open Journal Systems <p>The “<strong><em>Journal of Biological Sciences and Medicine</em></strong>” (JBSM) is an international open access journal in English published quarterly. The aim of JBSM is to publish rapid and peer reviewed original research articles, scientific reports, review and mini-reviews in the developing and interdisciplinary field of biological, environmental and medical sciences. We welcome original research papers covering all aspects of modern biology for publication in our journal. Aspiring young scientists, medical professionals and researchers especially in the field of biology, biomedicine, environmental sciences, agricultural sciences, forestry, biotechnology etc., are wholeheartedly encouraged to submit their valuable contributions.</p> <p>Journal of Biological Sciences and Medicine welcomes original, unpublished research papers which includes critical analysis of any aspect of all subjects from the faculty members, graduate students, independent researchers, and writers from all over the world. The scope of the journal is wide open to the International arena.</p> Distribution pattern of Helminthes parasites in Channa punctatus 2018-12-31T18:28:52+00:00 Neeshma Jaiswal Shruti Verma Sandeep K. Malhotra <p>The main aim of the present study is to expand knowledge about the prevalence and distribution pattern of helminth parasites in selected freshwater fish from River Gomti, Lucknow. The objectives of the present study were planned with the following to study the prevalence of helminth parasites in the selected fish <em>Channa punctatus</em>. A detailed analysis was conducted to find out the prevalence, abundance, intensity and index of infection of helminth parasites according to the body weight, body length of the fishes. During the present investigation, the prevalence, abundance, intensity and index of infection of genus <em>Pallisentis </em>was found at the rate of 50.94%, 1.21, 2.38 and 0.61 respectively. A high degree of infestation with helminth parasites in fresh water fish <em>C. punctatus</em> causes serious health concerns.</p> 2018-12-31T18:18:12+00:00 ##submission.copyrightStatement## Identification of nonsense mutation in TMC1 gene inducing hearing loss by clinical exome sequencing 2018-12-31T19:45:22+00:00 Maryam Alobathani Abdullah Al Mutery Walaa Kamal Eddine Ahmad Mohamed Abdelaziz Tlili <p>Hearing loss is one of the most common sensorineural disorders, affecting one in 1000 individuals that can be classified into syndromic and non-syndromic. <em>TMC1</em> gene has been identified as a non-syndromic gene for both autosomal and recessive forms. In this study, we characterized a UAE consanguineous family with congenital profound non-syndromic hearing loss. By using clinical exome sequencing, Sanger sequencing and PCR-RFLP, we identified the p.Arg34X as the disease-associated variant. The screening of other families with deafness, revealed the presence of this nonsense mutation in one additional family and suggested that p.Arg34X is major contributor to DFNB7/11 form of deafness in UAE population. To the best of our knowledge, this is the first study associating <em>TMC1</em> mutations to hearing loss in the GCC region.&nbsp;</p> 2018-12-31T18:27:18+00:00 ##submission.copyrightStatement## Seasonal and temporal intervention of endoparasitic helminths in fresh-water fish Wallago attu 2018-12-31T20:03:44+00:00 Anvita Tiwari Savita Kumari Neeshma Jaiswal <p>Fish represents a major group of organisms which serve as hosts for many parasites, ironically, they are one of the leading causes of mass mortality of fish populations. Freshwater fishes are heavily infected with a variety of helminths. The present study was aimed to check the availability of gastrointestinal parasites of <em>Wallago attu</em> fish in local fish markets of Lucknow in relation to the length and sex of fish. A significant amount of parasitic infection, especially endoparasites helminthes, some cestodes, trematodes and nematodes were observed in the infected fish during the present study.&nbsp; These parasites may cause great economic loss, hence adequate precautions should be taken into consideration to protect the great value of economic resources in the form of fish and aquaculture.</p> 2018-12-31T20:03:44+00:00 ##submission.copyrightStatement## Significance of medicinal plants against typhoid fever: Possible mechanism, effectiveness and outcomes 2018-12-31T18:28:52+00:00 Anand Singh Pavan Kumar Rashmi Srivastava <p>Typhoid fever one of the most severe bacterial disease have affected millions over the decades. It usually being treated with the administration of antibiotics as well as homeopathic medicines and traditional medicines which includes several medicinal plants. Such use of antibiotics against <em>Salmonella typhi</em> has increased the danger of increasing resistance of it against used antibiotics and thus decreasing the chances of its treatment in future. Homeopathic medicines prepared from several medicinal plants have been reported to be very effective against the <em>S. typhi</em> and its variants, thus have increased the chances of its treatment. Pharmacological profile of such medicinal plants extracts is still widely unknown and need further research. Moreover, all so far used medicinal plants, required pharmacological screening for their effectiveness against the effects of <em>S. typhi</em>.</p> 2018-09-30T00:00:00+00:00 ##submission.copyrightStatement##